COMPOUNDS AND METHODS OF TREATING NEUROLOGICAL DISORDERS

摘要

Embodiments of the present disclosure provide for compositions including a compound, pharmaceutical compositions including the compound, methods of treatment of a disease or related condition (e.g., neurological disease on condition), methods of treatment using compositions or pharmaceutical compositions, and the like.

主权项

1. A composition comprising: a compound having the following structure: wherein X is CR2R3, NR4, O, S, SO, or SO2, wherein R1 is selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group, wherein R2 and R3 are each independently selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group, and wherein R4 is selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group.