SUBSTITUTED ISOXAZOLE AMINE COMPOUNDS AS INHIBITORS OF SCD1

摘要

The invention is concerned with a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.;

主权项

1. A compound of formula (I) wherein A is —CH— or nitrogen; R1 is —O(CH2)nR4, —CH2NHR4, —CH2CH2R4, —OCH2C(O)R4 or —CH2OR4; R2 is hydrogen or halogen; R3 is hydrogen or lower alkyl; R4 is phenyl, pyridinyl, 1,1-dioxo-2,3-dihydro-1H-1lambda*6*-benzo[b]thiophenyl or 1,1-dioxo-1H-1lambda*6*-benzo[b]thiophenyl, said phenyl optionally mono- or bi-substituted independently with halogen, lower alkyl, alkoxy, —C(O)OCH3, —S(O)2CH3, —NO2, —CN, —CF3, —OCF3, —SCH3, —SO2-phenyl, —SCF3 or —SO2CH2CH3; and n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.