| 主权项 |
1. A compound having structural Formula I: or a pharmaceutically acceptable salt thereof, wherein: Z is ═C(R2)—; each of X1, X2 and X3 is independently selected from ═N— and ═C(R3)—; X4 is selected from ═N—, —C(═O)— and ═C(R3)—; X5 is no more than two of X1, X2, X3, X4, and X5 are ═N— or each R1 and R2 is independently selected from hydrogen, halo, —OH, —CN, C1-C4 alkyl, —O—(C1-C4 alkyl), N(R7)2, —(C0-C4 alkylene)-aryl, —(C0-C4 alkylene)-heteroaryl, —(C0-C4 alkylene)-heterocyclyl, —(C0-C4 alkylene)-carbocyclyl, —O—(C0-C4 alkylene)-aryl, —O—(C0-C4 alkylene)-heteroaryl, —O—(C0-C4 alkylene)-heterocyclyl, and —O—(C0-C4 alkylene)-carbocyclyl; each R3 is independently selected from hydrogen, halo, —OH, —CN, C1-C4 alkyl, C2-C4 alkenyl or alkynyl, —O—(C1-C4 alkyl), N(R7)2, —(C0-C4 alkylene)-aryl, —(C0-C4 alkylene)-heteroaryl, —(C0-C4 alkylene)-heterocyclyl, —(C0-C4 alkylene)-carbocyclyl, —O—(C0-C4 alkylene)-aryl, —O—(C0-C4 alkylene)-heteroaryl, —O—(C0-C4 alkylene)-heterocyclyl, —O—(C0-C4 alkylene)-carbocyclyl, —C(O)OR9, —C(O)N(R9)2, —S(O)R8, —S(O)2R8 and —S(O)2N(R9)2; R4—H is selected from hydrogen and CH3; R5—H is selected from —CH3, —CH(CH3)2, —(CH2)2CH3, —CH2CH3, —OCH2CH3, —OCH(CH3)2, —OCH3, —OCH2CH(CH3)2, —OH, —CH2OH, —(CH2)2OH, —(CH2)2—O—CH3, —NH—C(═O)—CH3, —(CH2)2—NH—CH3, —(CH2)2—NH—C(═O)—CH3, —CH2—C(═O)NH2, —NH—S(═O)2—CH3, and —NH—C(═O)—NH—CH3 R6 is hydrogen or methyl; each R7 is independently selected from hydrogen, —(C0-C4 alkylene)-R9, —(C2-C4 alkylene)-O—R9, C2-C4 haloalkyl, —S(O)2—R8, —C(═O)—R8, —C(═O)—N(R9)(R9), —(C2-C4 alkylene)-O—C(═O)—R8 and —(C0-C4 alkylene)-C(═O)—O—R9; or
two R7 are taken together with the nitrogen atom to which they are commonly bound to form an optionally substituted heterocyclyl or heteroaryl; R8 is selected from C1-C4 alkyl, aryl, heteroaryl, carbocyclyl and heterocyclyl; each R9 is independently selected from hydrogen and R8; and represents a single or double bond; wherein unless otherwise designated any alkyl, alkylene, alkenyl, alkenylene, alkynyl, alkynylene, aryl, heteroaryl, heterocyclyl or carbocyclyl portion of the compound is optionally substituted. |
