| 摘要 |
<p>The present invention provides a non-human mammalian animal model for type 2 diabetes, which spontaneously develops a pathological condition similar to human type 2 diabetes of a non-obese type seen in some Japanese people. The non-human mammalian animal model for type 2 diabetes according to the present invention is deficient in a Cdkal1 gene function on the chromosome of theβcell of the pancreas. More specifically, the non-human mammalian animal model for type 2 diabetes may be produced by interbreeding a non-human mammal carrying a site-specific recombination enzyme recognition sequence in the 3′-untranslated region and the 5′-untranslated region of a particular domain carrying one exon or more exons of the Cdkal1 gene with a non-human mammal in which a gene of a site-specific recombination enzyme capable of recognizing the site-specific recombination enzyme recognition sequence and splicing out the particular domain is inserted in such a manner as expressing specifically at a site downstream of a promoter of a gene expressing specifically in the pancreas.</p> |
