发明名称 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
摘要 3-Heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals The present invention relates to compounds of the formula I, wherein Ht, G, R 10 , R 30 , R 40 , R 50 and R 60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
申请公布号 EP2736888(B1) 申请公布日期 2015.11.04
申请号 EP20120738473 申请日期 2012.07.25
申请人 SANOFI 发明人 RUF, SVEN;PERNERSTORFER, JOSEF;SADOWSKI, THORSTEN;HORSTICK, GEORG;SCHREUDER, HERMAN;BUNING, CHRISTIAN;WIRTH, KLAUS
分类号 C07D249/10;A61K31/341;A61K31/4196;A61K31/421;A61K31/4245;A61K31/433;A61P9/00;A61P11/00;A61P25/28;A61P37/00;C07D263/34;C07D271/06;C07D271/10;C07D277/32;C07D285/08;C07D307/68 主分类号 C07D249/10
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