| 发明名称 |
COMT INHIBITORS |
| 摘要 |
The present invention relates to compounds of formula wherein the substituents are described in claim 1 and to the pharmaceutically acceptable salts thereof. These compounds inhibit the enzyme catechol-O-methyltransferase (COMT). The compounds may be used for the treatment of Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia. |
| 申请公布号 |
EP2938600(A1) |
申请公布日期 |
2015.11.04 |
| 申请号 |
EP20130820775 |
申请日期 |
2013.12.23 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
BISSANTZ, CATERINA;BONNAFOUS, RENÉ;BUETTELMANN, BERND;JAKOB-ROETNE, ROLAND;LERNER, CHRISTIAN;RUDOLPH, MARKUS |
| 分类号 |
C07D239/88;A61K31/517;A61P25/00;C07D401/04;C07D401/10;C07D401/12;C07D403/04;C07D403/10;C07D405/04;C07D409/04;C07D409/14;C07D413/04;C07D417/04;C07D417/10;C07D471/04 |
主分类号 |
C07D239/88 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
