发明名称 |
USE OF ALGINATE COMPOSITIONS IN PREVENTING OR REDUCING LIVER DAMAGE CAUSED BY A HEPATOTOXIC AGENT |
摘要 |
Compositions comprising an alginate, a source of sodium ions and a carrier (e.g., a pharmaceutically acceptable carrier), which are characterized by reduced association of the alginate chains and hence by at least one of: (i) a zeta potential weaker than −25 mV, at a concentration of 0.5% (w/v) alginate in the carrier; and (ii) a diffusion coefficient of at least 10−8 cm2/millisecond, at a concentration of 0.5% (w/v) alginate in the carrier, are disclosed. Also disclosed are uses of the composition and methods utilizing the composition for treating inflammatory bowel disease, liver damage, diseases and disorders, for treating a medical condition treatable by a hepatotoxic agent and for reducing or preventing liver damage, including liver damage caused by a hepatotoxic agent. |
申请公布号 |
EP2938347(A1) |
申请公布日期 |
2015.11.04 |
申请号 |
EP20130869473 |
申请日期 |
2013.12.30 |
申请人 |
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT;B.G. NEGEV TECHNOLOGIES & APPLICATIONS LTD. AT BEN-GURION UNIVERSITY |
发明人 |
COHEN, SMADAR;ILAN, YARON;SHTEYER, EYAL;BEN-YA'ACOV, AMI |
分类号 |
A61K31/734;A61K31/738;A61P1/16 |
主分类号 |
A61K31/734 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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