| 摘要 |
<p>According to an aspect of the present invention, urological medical devices are provided, which contain one or more urologically beneficial agents selected from alpha-adrenergic blockers, calcium channel blockers, and combinations thereof, among others. The urological devices are adapted for implantation or insertion into a subject's urinary tract, whereupon at least a portion of the urologically beneficial agent is released. Such agents are urologically beneficial, for example, in that they may relieve pain and/or discomfort associated with the medical device and/or act as stone expulsion agents (i.e., they facilitate stone passage), among other benefits. According to an aspect of the present invention, a method of treating kidney stones is provided which comprises: (a) diagnosing the presence of kidney stones within a subject and (b) implanting or inserting a urological medical device into the subject which contains at least one urologically beneficial agent. The medical device is adapted to release the at least one urologically beneficial agent in vivo in an amount effective to promote kidney stone expulsion.</p> |
