METHOD FOR PRODUCING DIFLUOROACETIC ACID ESTER

摘要

A production method of a difluoroacetic acid ester according to the present invention includes at least: a reaction step of obtaining a liquid by reaction of an alcohol represented by ROH with difluoroacetic acid fluoride (CHF 2 COF) in the presence of an amide compound of the following formula (1) or a sulfone compound of the following formula (2) as a hydrogen fluoride trapping agent; and a distillation step (A) of extracting a difluoroacetic acid ester represented by CHF 2 COOR by distillation of the reaction liquid obtained in the first step.
In the present production method, there occurs no deterioration in the yield of the product due to the inherent generation of hydrogen fluoride as a by-product during the esterification reaction of difluoroacetic acid fluoride.