| 发明名称 |
METHOD OF REGULATING CFTR EXPRESSION AND PROCESSING |
| 摘要 |
<p>The present invention relates to therapeutic agents comprising miR-138, a miR-138 mimic, a SIN3A RNAi molecule, or a an anti-SIN3A RNAi molecule, and/or an anti-SIN3A antisense oligonucleotide (ASO) or other agent that suppresses SIN3A expression, a small molecule drug that interferes with SIN3A activity or whose actions mimic the biological effects of SIN3A suppression and methods of use of these therapeutic agents to treat cystic fibrosis.</p> |
| 申请公布号 |
EP2812031(A4) |
申请公布日期 |
2015.11.04 |
| 申请号 |
EP20130746389 |
申请日期 |
2013.02.06 |
| 申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION;INTEGRATED DNA TECHNOLOGIES, INC. |
发明人 |
MCCRAY, PAUL;RAMACHANDRAN, SHYAM;XING, YI;WELSH, MICHAEL;BEHLKE, MARK |
| 分类号 |
A61K48/00;A61K31/713;C12N15/113 |
主分类号 |
A61K48/00 |
| 代理机构 |
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