| 摘要 |
<p>Disclosed are a composition of glucose derivative and proline, a crystal, a preparation method and an application. In an X-ray powder diffraction diagram of the eutectic crystal when the diffraction angle is 2¸, characteristic diffraction peaks comprise 4.339, 11.499, 12.835, 13.921, 15.294, 16.212, 16.804, 17.154, 18.335, 19.274, 19.982, 22.710, 23.218, 24.885, 27.940, 29.612 and 30.313, and the 2¸ error range is ±0.1. The method comprises: mixing a compound A solution with an L-proline solution, and performing cooling and crystallization. The present invention furhter provides an application of the crystal in medicine preparation. The eutectic crystal in the present invention features high water-solubility, low hygroscopicity and high stability, and is suitable for manufacturing a variety of preparations.</p> |
