发明名称 |
NEW COMPOUNDS FOR MODULATING THE ACTIVITY OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) |
摘要 |
<p>The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. Examples of the compounds of the invention are substituted deoxyadenosine-cyclic monosphosphates. The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of diseases like cancer, chronic inflammation, thrombosis and/or type-2 diabetes mellitus in humans and/or animals.</p> |
申请公布号 |
EP1511757(B1) |
申请公布日期 |
2015.11.04 |
申请号 |
EP20030757062 |
申请日期 |
2003.06.10 |
申请人 |
UNIVERSITAIR MEDISCH CENTRUM UTRECHT |
发明人 |
DE KONING, JOHN;CHRISTENSEN, ANNE;SCHWEDE, FRANK;GENIESER, HANS, GOTTFRIED;DOSKELAND, STEIN;BOS, JOHANNES |
分类号 |
C07H19/213;A61K31/7076;A61P3/10;A61P7/02;A61P29/00;A61P35/00;A61P43/00 |
主分类号 |
C07H19/213 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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