Methods of diagnosing endometriosis

摘要

The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis.

主权项

1. A method for detecting the expression of biomarkers in a biological sample comprising endometrial cells or tissue from a human subject, the method comprising:
detecting in the biological sample expression of a gene or protein, wherein said gene or protein is selected from the group consisting of: Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B (APOBEC3B); DEAD (Asp-Glu-Ala-Asp) box polypeptide (DEAD/H); Fibrillin 1 (FBN1); Major histocompatibility complex, class II, DOB (HLA-DOB); Lactotransferrin (LTF); Orosomucoid 2 (ORM2); Phospholipase C, beta 4 (PLCB4); POM (POM121 homolog, rat) and ZP3 fusion (POMZP3); Phosphatidic acid phosphatase, type 2B (PPAP2B); and Solute carrier family 15, member 2 (SLC15A2).