Potent non-urea inhibitors of soluble epdxide hydrolase

摘要

The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.

主权项

1. A method for inhibiting the activity of a soluble epoxide hydrolase which comprises contacting the soluble epoxide hydrolase with a compound of Formula I in an amount effective to inhibit soluble epoxide hydrolase activity, wherein Formula I is: wherein R1 is independently selected for each occurrence from the group consisting of wherein R2 is independently selected for each occurrence from the group consisting of and further wherein, when R2 isR1 is not and pharmaceutically acceptable salts and prodrugs thereof.