| 发明名称 | Method for inducing extended self-renewal of functionally differentiated somatic cells | ||
| 摘要 | Mouse or human hematopoietic cells are transduced in vitro with one or more vectors encoding c-Myc and Klf4 genes, to overexpress both c-Myc and Klf4. The transduced cells produce self-renewing populations of macrophages, monocytes, monocyte-derived macrophages, B lymphocytes or erythroid cells. The self-renewing cell populations may include a pharmaceutical composition. | ||
| 申请公布号 | US9175265(B2) | 申请公布日期 | 2015.11.03 |
| 申请号 | US201013382724 | 申请日期 | 2010.07.08 |
| 申请人 | Institut National de la Sante et de la Recherche Medicale (INSERM);Centre National de la Recherche Scientifique (CNRS);Universite de la Mediterranee (Aix-Marseille II) | 发明人 | Sieweke Michael |
| 分类号 | C12N5/00;C12N15/00;C12N15/63;A61K48/00;C07H21/04;C12N5/0786;C12N5/0781;C12N15/85;C12N15/86;C12N15/90;C12N5/078;A61K35/12 | 主分类号 | C12N5/00 |
| 代理机构 | Whitham, Curtis, Christofferson & Cook, P.C. | 代理人 | Whitham, Curtis, Christofferson & Cook, P.C. |
| 主权项 | 1. A method for inducing extended self-renewal of mouse or human macrophages, B lymphocytes or erythroid cells comprising a step of activating overexpression of a c-Myc gene and a Klf4 gene in said cells by transducing said cells in vitro with a retroviral vector encoding c-Myc and said Klf4 gene. | ||
| 地址 | Paris FR | ||