发明名称 |
Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof |
摘要 |
Disclosed herein, in certain embodiments, is a crystalline polymorph form A of N—(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide. Further disclosed herein, in certain embodiments, are pharmaceutical compositions comprising the crystalline polymorph form A of N—(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide. |
申请公布号 |
US9174933(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US201414311720 |
申请日期 |
2014.06.23 |
申请人 |
ARDEA BIOSCIENCES, INC. |
发明人 |
Dimock Stuart |
分类号 |
C07C303/44;C07C311/28 |
主分类号 |
C07C303/44 |
代理机构 |
Millen, White, Zelano & Branigan, P.C. |
代理人 |
Millen, White, Zelano & Branigan, P.C. |
主权项 |
1. A method for the treatment or therapy of a cancer of a biliary or digestive organ, which does not comprise prevention thereof, comprising administering to a subject in need thereof 50 mg of N—(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl) cyclopropane-1-sulfonamide twice daily, wherein no other drug is administered to said patient for the treatment or therapy of said cancer of the biliary or digestive organ, which cancer is of the bile duct, the intrahepatic bile duct or the gallbladder. |
地址 |
San Diego CA US |