主权项 |
1. A compound of Formula (A) wherein: groups attached to the ring containing Q that are depicted inside the ring are all syn to each other, and all groups attached to that ring that are depicted outside the ring are syn to one another; Q is C or N; Rq is H when Q is C, and Rd is absent when Q is N; R1 is selected from H, C1-4 alkyl, C3-6 cycloalkyl, C4-6 heterocyclyl, —(CR′2)1-3—OR′ and —OR′,
where each R′ is independently H or C1-4 alkyl,
and each alkyl, cycloalkyl and heterocyclyl is optionally substituted with up to two groups selected from halo, CN, NH2, hydroxy, oxo, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy; R1b, R1c, and R1d are each independently selected from H, halo, OR′, R′, —(CH2)1-2OR′, and CONR′2; one of R2a and R2b is H, and the other of R2a and R2b is selected from CN, azido, amino, —OR, —O(CH2)1-3OR, —NRC(O)R, —NRC(O)OR, —NHSO2R, —SO2R, —OSO2R, —SR, —S(O)R, —OP(O)R2, and 1-pyridonyl or 1-triazolyl optionally substituted with up to two groups selected from halo, C1-4 alkyl, hydroxy-substituted C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, C1-4 alkoxy, and C5-6 heteroaryl;
where each R is independently C5-6 heteroaryl or C1-4 alkyl optionally substituted with up to three groups selected from cyano, halo, hydroxy, carboxy, C1-4 alkylsulfonyl, and C1-4 alkoxy; or R2a and R2b taken together may form a dialkyl ketal or 5-6 membered cyclic ketal, ═O or ═N—OR″, where R″ is H or C1-4 alkyl; ring A is selected from pyridinyl, pyrimidinyl, and pyrazinyl, each having N positioned as shown in Formula (I); and Ring A is optionally substituted with 1 or 2 groups selected from halo, CN, NH2, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy;or a pharmaceutically acceptable salt thereof. |