In situ forming hemostatic foam implants

摘要

Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

主权项

1. A system for forming a medical implant to limit movement of a bodily fluid, comprising:
a first chamber containing a first composition, the first composition including a polyol comprising up to 50 weight percent polyethylene oxide, up to 10 pphp of an amine catalyst, and up to 20 pphp water; a second chamber containing a second composition, the second composition including a multifunctional isocyanate; a mechanism that places the first composition into contact with the second composition thereby forming a polyurethane foam; and a nozzle insertable into a body of a patient, the nozzle configured to permit the flow of a mixture of the first and second compositions into a body cavity of the patient; wherein said foam is configured to control movement of bodily fluids when formed while in contact with bodily tissue; wherein the foam is characterized by a rise time of up to 150 seconds.