Methods for forming stent coatings comprising hydrophilic additives

摘要

A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically entangled or interpenetrating system.

主权项

1. A method of fabricating a coating for an implantable medical device comprising:
providing an implantable medical device; preparing a solution comprising at least one hydrophobic polymer comprising a macromolecular chain, at least one hydrophilic polymer comprising a macromolecular chain, and either a solvent or a blend of solvents; applying the solution to the implantable medical device; and removing the solvent or the blend of solvents; wherein a physically entangled or intertwined system is formed of the macromolecular chains of the hydrophobic polymer and the hydrophilic polymer; and wherein at least one hydrophobic polymer is selected from the group consisting of polyurethaneureas with a Hildebrand solubility parameter (δ) of less than 10.7 (cal/cm3)1/2.