发明名称 Pyrrolotriazinone derivatives
摘要 Compounds of the formula I; in which X, R1 and Y have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
申请公布号 US9174995(B2) 申请公布日期 2015.11.03
申请号 US201314398212 申请日期 2013.04.06
申请人 MERCK PATENT GMBH 发明人 Dorsch Dieter;Buchstaller Hans-Peter
分类号 C07D487/04;C07D403/04;C07D403/10;A61K31/53;A61P19/02 主分类号 C07D487/04
代理机构 Millen, White, Zelano, Branigan, P.C. 代理人 Millen, White, Zelano, Branigan, P.C.
主权项 1. A compound selected from the following group:No.Name“A1”2-p-tolyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A2”4-(4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-benzoicacid methyl ester“A3”2-(4-tert-butyl-phenyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A4”2-(1-acetyl-piperidin-4-yl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A5”2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-3H-pyrrolo-[2,1-f][1,2,4]triazin-4-one“A6”2-(4-bromo-phenyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A7”2-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-3H-pyrrolo-[2,1-f][1,2,4]triazin-4-one“A8”2-(4-pyrrolidin-l-ylphenyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A9”2-cyclohexyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A10”2-(1-tert-butylpyrazol-4-yl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A11”2-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-3H-pyrrolo [2,1-f][1,2,4]triazin-4-one“A12”6-fluoro-2-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-3H-pyrrolo [2,1-f][1,2,4]triazin-4-one“A13”6-methyl-2-[4-(1-methylpyrazol-4-yl)phenyl]-3H-pyrrolo-[2,1-f][1,2,4]triazin-4-one“A14”2-[4-(1-ethyl-1-hydroxy-propyl)-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A15”2-{4-[1-(2-hydroxy-ethoxy)-1-methyl-ethyl]-phenyl}-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A16”2-[4-(1-amino-1-methyl-ethyl)-phenyl]-3H-pyrrolo[2,1-f][1,2,4]-triazin-4-one“A17”6-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-2-methyl-5H-1,5,7,7a-tetraaza-inden-4-one“A18”6-chloro-2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-3H-pyrrolo [2,1-f][1,2,4]triazin-4-one“A19”2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-7-methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A20”2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-7-trifluoromethyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one“A21”2-[4-(1-hydroxy-cyclopentyl)-phenyl]-3H-pyrrolo[2,1-f][1,2,4]-triazin-4-one and pharmaceutically acceptable solvates, salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.
地址 Darmstadt DE