Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators

摘要

Novel compounds of structure Formula I: (I) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are defined herein, are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the GPR119 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.;

主权项

1. A compound of formula I enantiomer, diastereomer, tautomer, or salt thereof wherein: R1 is hydrogen or halo; R2 is (C1-C10)alkyl; and R3 is halo or (C1-C10)alkyl.