TSH receptor antagonizing tetrahydroquinoline compounds

摘要

The present invention relates the use of a compound, a pharmaceutical composition, compounds and a kit for treating or preventing disorders in a mammal responsive to TSH receptor mediated pathways, including disorders such as hyperthyroidism, Graves' disease, Graves Ophthalmopathy, Graves' associated pretibial dermopathy, nodular goitre and thyroid cancer comprising administering to said mammal an effective amount of a tetrahydroquinoline compound of Formula (I) or an pharmaceutically acceptable salt thereof.;

主权项

1. A compound selected from the group consisting of
1) N-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro-quinolin-6-yl)-2-phenoxy-acetamide, and 2) N-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro-quinolin-6-yl)-3-thiophen-2-yl-propionamide.