Variable-depth stereotactic surface projections

摘要

An implementation of SSP using variable depth for the vectors extending normal to the surface voxels of the brain so as to avoid white matter uptake extraction is provided. The implementation also provides the possibility to compare SSP for an individual amyloid imaging agent image to a SSP normal database and allows for 3D visualization of SSP information.

主权项

1. A method of stereotactic surface projection of a PET/SPECT image comprising the steps of;
(a) spatially normalizing a PET/SPECT image, wherein each voxel on the surface of a brain is registered to a standard space, and (b) calculating SSP for each surface voxel of the spatially normalized PET/SPECT image, wherein, said calculating step further comprises calculating the maximum intensity along a line extending from each surface voxel and perpendicular to the surface into the tissue such that each line extends to a predefined maximum depth that is calculated individually for each surface voxel.