Drug products, dry powder inhalers and polyflux collider arrangements

摘要

This disclosure relates to dry powder inhalers and drug products and, more particularly to polyflux colliders useful for de-agglomerating dry powder in dry powder dispensers. Various embodiments provide drug products, dry powder inhalers and polyflux collider arrangement. With various embodiments of the present invention, a polyflux collider is provided which utilizes colliding streams of dry powder to provide desirable de-agglomerating capability for dry powder dispensers.

主权项

1. A polyflux collider arrangement for de-agglomerating dry powder in a powder dispenser during inhalation of a dose of dry powder, said polyflux collider arrangement comprising:
spaced-apart first and second inlet openings, a reference plane passing through the centers of said first and second inlet openings; and, a polyflux collider having a body at least partially encompassing a volume and a single exit opening, wherein said first and second inlet openings and said exit opening being in communication with an encompassed volume, said exit opening being spaced from said reference plane; wherein, the center of said exit opening having a reference axis passing therethrough, said reference axis being perpendicular to said reference plane, said reference axis being spaced and offset from the centers of said first and second inlet openings, and wherein, upon inhalation of a dose, negative pressure is applied to said exit opening which causes a first stream of dry powder to be entrained from said first inlet opening into said encompassed volume and directed towards said exit opening, said negative pressure also causing a second stream of dry powder to be entrained from said second inlet opening into said encompassed volume and directed towards said exit opening, said first and second streams of dry powder colliding in said encompassed volume to form a collective stream passing through said exit opening, said collective stream defining the dose of dry powder.