Recombinant modified vaccinia virus Ankara influenza vaccine

摘要

The invention concerns a recombinant modified vaccinia virus Ankara (MVA virus) expressing at least two external influenza virus antigens and/or an epitope of one or more of the at least two antigens and at least two internal influenza virus antigens and/or an epitope of the at least two antigens. The invention, thus, concerns a recombinant MVA virus encoding multiple external and/or internal influenza virus antigens, preferably from multiple influenza virus strains. The invention further concerns the use of said recombinant MVA in preparing a medicament and vaccine for influenza virus. Further encompassed by the present invention are methods, composition and kits.

主权项

1. A modified vaccinia virus Ankara (MVA) comprising at least 11,000 nucleotides of influenza nucleic acid sequences encoding at least 5 external influenza virus antigens and at least 3 internal influenza virus antigens, wherein the nucleic acid sequences encoding the antigens are inserted into at least two MVA insertion sites,
wherein the external influenza virus antigens comprise at least 3 different hemagglutinin antigens selected from hemagglutinin 2 (H2), hemagglutinin 9 (H9), hemagglutinin 5 (H5), and hemagglutinin 7 (H7) antigens.