Human soluble receptor for advanced glycation end products (sRAGE), methods of preparing human sRAGE, and treatment methods using sRAGE

摘要

The present disclosure provides a method for recombinant production of human sRAGE in mammalian cells, as well as a human sRAGE having a mammalian post-translational modification and compositions thereof. The present disclosure also provides a method of treating a vascular disease, injury, or inflammation in a mammal by administering to a mammal with a vascular disease, injury, or inflammation a composition comprising human sRAGE having a mammalian post-translational modification, thereby treating the vascular disease, injury, or inflammation in the mammal.

主权项

1. A method of treating a vascular disease, vascular injury or vascular inflammation in a mammal, comprising administering to the mammal an isolated human soluble receptor for advanced glycation end products (sRAGE) polypeptide comprising a mammalian post-translation modification, wherein the amino acid sequence of the sRAGE polypeptide is at least 95% identical to SEQ ID NO: 4 and the mammalian post-translation modification comprises mammalian N-glycosylation, thereby treating the vascular disease, vascular injury, or vascular inflammation in the mammal.