发明名称 |
Compositions and methods for the treatment of cardiac surgery-associated acute kidney injury with annexin A1 peptide |
摘要 |
The present invention provides a method of treating, ameliorating and/or preventing cardiac surgery-associated acute kidney injury (AKI) in a subject, comprising administering to the subject a therapeutically effective amount of an annexin A1 (ANXA1) peptide such that the AKI is treated, ameliorated and/or prevented. |
申请公布号 |
US9173918(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US201113879558 |
申请日期 |
2011.10.14 |
申请人 |
Duke University |
发明人 |
Zhang Zhiquan;Mackensen G. Burkhard;Ma Qing;Podgoreanu Mihai V. |
分类号 |
A61K38/06;C07K5/08;A61P13/12;A61K38/07;A61K38/17 |
主分类号 |
A61K38/06 |
代理机构 |
Myers Bigel Sibley & Sajovec, P.A. |
代理人 |
Myers Bigel Sibley & Sajovec, P.A. |
主权项 |
1. A method of treating acute kidney injury (AKI) due to cardiac surgery or cardiac transplantation in a subject having cardiac surgery or cardiac transplantation, comprising administering to said subject an effective amount of an annexin A1 short peptide (ANXA1sp) consisting of the amino acid sequence Ac-Gln-Ala-Trp, wherein the ANXA1sp is administered to the subject prior to, during and/or after cardiac surgery or cardiac transplantation, thereby treating AKI due to cardiac surgery or cardiac transplantation. |
地址 |
Durham NC US |