Systems and methods for the identification of compounds in medical fluids using admittance spectroscopy

摘要

Described herein are devices, systems, and methods for determining the composition of fluids, and particularly for describing the identity and concentration of one or more components of a medical fluid such as intravenous fluid. These devices, systems and methods take multiple complex admittance measurements from a fluid sample in order to identify the identity and the concentration of components of the fluid. The identity and concentration of all of the components of the solution may be simultaneously and rapidly determined. In some variations, additional measurement or sensing modalities may be used in addition to admittance spectroscopy, including optical, thermal, chemical, etc.

主权项

1. A system for determining the identity, concentration or identity and concentration of an intravenous drug solution by admittance spectroscopy to determine surface interactions of the intravenous drug solution on fluid-contacting surfaces of a plurality of pairs of electrodes, the system comprising:
a sensor comprising a plurality of pairs of electrodes having fluid-contacting surfaces, wherein each pair of electrodes is configured to have different surface interactions with the solution at different frequencies than the other pairs of electrodes; a signal generator configured to provide current at a plurality of frequencies for application from one or more fluid-contacting surfaces of the sensor; a signal receiver configured to receive complex admittance data from a plurality of fluid-contacting surfaces of the sensor; a controller configured to coordinate the application of signals from the signal generator and the acquisition of complex admittance data from the sensor to create an admittance spectrographic fingerprint of the intravenous drug solution, wherein the controller is configured to apply electrical excitation to each pair of electrodes that results in a voltage that is below 500 mV and below the threshold level for electrochemical reactions, further wherein the admittance spectrographic fingerprint comprises complex admittance information indicative of surface interactions between the intravenous drug solution and the fluid-contacting surfaces of the sensor; and a processor configured to receive the admittance spectrographic fingerprint and to determine the identity, concentration or identity and concentration of the intravenous drug solution by comparing the admittance spectrographic fingerprint to a library of admittance spectrographic data comprising complex admittance data measured from a plurality of known compounds and mixtures of compounds in a carrier solution at a plurality of frequencies and known concentrations.