发明名称 |
Monoclonal antibody capable of binding to anexelekto, and use thereof |
摘要 |
The present inventors have succeeded in producing anti-AXL antibodies with specific functions. The present inventors also discovered that the antibodies have an angiogenesis-suppressive effect and an antitumor effect, and thereby completed the present invention. The anti-AXL antibodies of the present invention are useful as angiogenesis inhibitors and agents for inducing or inhibiting phosphorylation activity. |
申请公布号 |
US9175091(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US200812742947 |
申请日期 |
2008.11.14 |
申请人 |
Chugai Seiyaku Kabushiki Kaisha |
发明人 |
Kitazawa Takehisa;Suzuki Tsukasa;Nagahashi Shigehisa;Miyamoto Hajime |
分类号 |
C07K16/00;C07K16/32;C07K16/40;A61K39/00 |
主分类号 |
C07K16/00 |
代理机构 |
Fish & Richardson P.C. |
代理人 |
Fish & Richardson P.C. |
主权项 |
1. A monoclonal anti-AXL antibody according to any of the following (a) to (b):
(a) a monoclonal antibody (Ax284) produced from a hybridoma deposited with the International Patent Organism Depositary (IPOD), National Institute of Advanced Industrial Science and Technology (AIST) and assigned Accession No. FERM BP-10857; and (b) a monoclonal antibody (Ax225) produced from a hybridoma deposited with the IPOD, AIST, and assigned Accession No. FERM BP-10854. |
地址 |
Tokyo JP |