| 发明名称 | Immunoglobulin G Fc region binding polypeptide | ||
| 摘要 | An immunoglobulin G Fc region binding polypeptide is provided, consisting of an amino acid sequence selected from i) a variant of Protein A domain or Protein Z and ii) an amino acid sequence which has at least 95% identity thereto. Also provided are methods for producing the polypeptide, compositions comprising the polypeptide, polynucleotides encoding the polypeptide, multimers of the polypeptide, and methods of using the polypeptide. | ||
| 申请公布号 | US9175067(B2) | 申请公布日期 | 2015.11.03 |
| 申请号 | US201113583686 | 申请日期 | 2011.03.07 |
| 申请人 | GE Healthcare Bio-Sciences AB | 发明人 | Abrahmsen Lars |
| 分类号 | C07K16/00;B01D15/38;B01J20/28;B01J20/285;B01J20/286;B01J20/32;C07K14/31;C07K16/06 | 主分类号 | C07K16/00 |
| 代理机构 | Parks Wood LLC | 代理人 | Parks Wood LLC |
| 主权项 | 1. An immunoglobulin G Fc region binding polypeptide, comprising an mamino acid sequence:i) X1-([spacer1]-(SEQ ID NO: 10)-X17LPX20-(SEQ ID NO: 11)-X36-(SEQ ID NO: 12)-X51-(SEQ ID NO: 13)-[spacer2])n-CCTERM-1XCTERM wherein, independently of each other, X1 is P or nothing; [spacer1] is an amino acid sequence consisting of 1-3 amino acid residues; X17 is any amino acid residue; X20 is any amino acid residue; X36 is any amino acid residue except for D; X51 is any amino acid residue; [spacer2] is an amino acid sequence consisting of 0-20 amino acid residues; XCTERM is D or nothing; and n is 1-4. | ||
| 地址 | Uppsala SE | ||