发明名称 |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
摘要 |
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein. |
申请公布号 |
US9174982(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US201314038304 |
申请日期 |
2013.09.26 |
申请人 |
ABBVIE INC.;GENENTECH, INC.;THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH |
发明人 |
Bruncko Milan;Ding Hong;Doherty George A.;Elmore Steven W.;Hasvold Lisa A.;Hexamer Laura;Kunzer Aaron R.;Song Xiaohong;Souers Andrew J.;Sullivan Gerard M.;Tao Zhi-Fu;Wang Gary T.;Wang Le;Wang Xilu;Wendt Michael D.;Mantei Robert A.;Hansen Todd M. |
分类号 |
C07D209/82;C07D403/12;C07D401/14;C07D471/04;C07D519/00;A61K31/496 |
主分类号 |
C07D209/82 |
代理机构 |
Jones Day |
代理人 |
Jones Day |
主权项 |
1. A method of treating a cancer selected from the group consisting of chronic lymphocytic leukemia, lymphoblastic leukemia, follicular lymphoma, a lymphoid malignancy of T cell or B cell origin, myelogenous leukemia, myeloma and breast cancer in a patient, said method comprising administering to the patient a therapeutically effective amount of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide or a pharmaceutically acceptable salt thereof. |
地址 |
North Chicago IL US |