Mixer with zero dead volume and method for mixing

摘要

A micro fluidics system includes a closed, expandable volume for mixing a fluid, and a flexible membrane for allowing mixing in the closed, expandable volume. The system further includes a surface having at least one channel for fluidically coupling a first side of the surface to the closed, expandable volume on a second side of the surface. The channel includes a first channel opening fluidically coupling the first side of the surface to the channel and a second channel opening fluidically coupling the channel to the closed, expandable volume. The expandable volume is defined by the flexible membrane closing the second channel opening when there is no fluid in the expandable volume.

主权项

1. A microfluidics system comprising:
a closed, expandable volume for mixing a fluid; a flexible membrane for allowing mixing in the closed, expandable volume; a directional valve; and a surface comprising a plurality of channels for fluidically coupling a first side of the surface to the closed, expandable volume on a second side of the surface, wherein a first channel of the plurality of channels comprises a first channel opening fluidically coupling the first side of the surface to the first channel and a second channel opening fluidically coupling the first channel to the closed, expandable volume, the expandable volume being defined by the flexible membrane closing the second channel opening when there is no fluid in the expandable volume, wherein the directional valve is configured to allow passage of the fluid in only one direction by allowing the fluid to enter the closed, expandable volume through the first channel and preventing exit of the fluid from the closed, expandable volume through the first channel.