Touch-actuated micropump for transdermal drug delivery and method of use

摘要

A micropump device. The micropump device includes a first layer forming a first chamber configured to store a working material, a second chamber defined by a deflectable membrane in fluid communication with the first chamber and configured to deflect in response to a pressure increase in the first chamber in response to a volume increase in the first chamber, the second chamber configured to store a drug compound to be delivered to a subject's vascular system, and at least one needle in fluid communication with the second chamber and configured to penetrate a subject's skin to pump the drug compound in response to the deflection of the deflectable membrane.

主权项

1. A micropump device, comprising:
a first layer forming a first chamber storing a working material; a second chamber defined by a deflectable membrane separating the second chamber from the first chamber and configured to deflect in response to a volume increase in the first chamber, the second chamber storing a drug compound to be delivered to a subject's vascular system; and at least one needle in fluid communication with the second chamber and configured to penetrate a subject's skin to pump the drug compound in response to deflection of the deflectable membrane; wherein the working material in the first chamber is a phase-change material that increases in volume in response to application of heat from a user's skin to the first layer, the deflectable membrane in fluid contact with the phase-change material in the first chamber and in fluid contact with the drug compound in the second chamber.