| 发明名称 |
RNAi-mediated inhibition of connexin 43 for treatment of IOP-related conditions |
| 摘要 |
RNA interference is provided for inhibition of connexin 43 (Cx43) in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma. |
| 申请公布号 |
US9173896(B2) |
申请公布日期 |
2015.11.03 |
| 申请号 |
US200912371007 |
申请日期 |
2009.02.13 |
| 申请人 |
Arrowhead Research Corporation |
发明人 |
Chatterton Jon E.;Clark Abbot F.;Wax Martin B. |
| 分类号 |
A61K31/713;C12N15/113 |
主分类号 |
A61K31/713 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating glaucoma in a patient that has elevated intraocular pressure (IOP), consisting of administering to the eye of the patient an interfering RNA molecule comprising SEQ ID NO: 79 or SEQ ID NO: 80, wherein the interfering RNA molecule comprises an acceptable carrier, and wherein attenuating expression of Cx43 lowers intraocular pressure in the patient. |
| 地址 |
Pasadena CA US |
