| 发明名称 | Compositions and methods for inhibiting expression of TMPRSS6 gene | ||
| 摘要 | The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the TMPRSS6 gene, and methods of using such dsRNA compositions to inhibit expression of TMPRSS6. | ||
| 申请公布号 | US9175290(B2) | 申请公布日期 | 2015.11.03 |
| 申请号 | US201214007835 | 申请日期 | 2012.03.28 |
| 申请人 | Alnylam Pharmaceuticals, Inc. | 发明人 | Bumcrot David;Bettencourt Brian;Toudjarska Ivanka |
| 分类号 | C12N15/11;C07H21/02;C12N15/113;A61K31/713 | 主分类号 | C12N15/11 |
| 代理机构 | Lando & Anastasi, LLP | 代理人 | Lando & Anastasi, LLP |
| 主权项 | 1. A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of TMPRSS6, wherein said dsRNA comprises a sense strand and an antisense strand, wherein said antisense strand comprises a region of complementarity to a TMPRSS6 RNA transcript comprising a sequence selected from the group consisting of SEQ ID NO:420, SEQ ID NO:112, SEQ ID NO:110, SEQ ID NO:90, and SEQ ID NO:48, and wherein said dsRNA comprises at least one modified nucleotide. | ||
| 地址 | Cambridge MA US | ||