System for blood separation with replacement fluid apparatus and method

摘要

A method is provided in a centrifugal blood processing system for adding replacement fluid without a dedicated peristaltic pump to blood components being returned to the donor. A disposable blood processing set for use in the method comprises a hermetically sealed set of blood bags, connecting tubes, needles or connectors, and supporting structures with a replacement fluid line coupled directly to a return reservoir without contact with an intervening pump.

主权项

1. A method of providing a controlled amount of blood replacement fluid to a blood donor comprising:
providing a disposable blood processing set for use on a centrifugal blood processing device, said disposable set comprising: a blood separation chamber adapted to be mounted on a rotor of said centrifugal blood processing device; a blood inlet line adapted to be coupled to a blood donor and to an inlet pump on said centrifugal blood processing device; an anti-coagulant line in fluid communication with said inlet line, said anti-coagulant line being adapted to be fluidly coupled to a supply of anti-coagulant and being further adapted to be coupled to an anti-coagulant pump on said centrifugal blood processing device; a reservoir adapted to be coupled to at least one sensor for detecting a level of fluid in said reservoir; a return line in fluid communication with said reservoir, said return line being adapted to be coupled to said blood donor and to a return pump on said centrifugal blood processing device; a red blood cell line in fluid communication with said blood separation chamber and said reservoir; a collect line in fluid communication with said blood separation chamber and in selective communication with said reservoir and a collect bag, said collect line being adapted to be coupled to a collect pump; a plasma line in fluid communication with said blood separation chamber and with said reservoir, said plasma line being adapted to be coupled to a plasma pump; and a replacement fluid line in fluid communication with said reservoir and adapted to be placed in fluid communication with a source of replacement fluid; mounting said disposable blood processing set on said centrifugal blood processing device; removing whole blood from said donor through said inlet line; providing anti-coagulant to said whole blood in said inlet line; measuring the flow of said whole blood and said anti-coagulant in said inlet line; separating said whole blood and said anti-coagulant into a plurality of blood components in said separation chamber; flowing red blood cells from said separation chamber into said reservoir; flowing a first blood component from said separation chamber into said reservoir; measuring the flow of said first blood component into said reservoir; removing a second blood component from said separation chamber; measuring the flow of said second component; selectively flowing at least part of said second component into said reservoir; selectively flowing replacement fluid into said reservoir; periodically flowing contents of said reservoir into said return line; measuring the flow of said contents; determining a quantity of replacement fluid delivered to said donor from said measured inlet line flow, first blood component flow, collect flow and return flow.