发明名称 |
Inhibitors of phosphodiesterase 11 (PDE11) |
摘要 |
The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency. Another aspect relates to kits comprising PDE11 inhibitors for administration to a subject, pharmaceutical compositions comprising compounds of formula (I)-(VI) for use in methods to increase cortisol levels and/or treat adrenal insufficiency, and their use as an adjuvant for treatment of cancer or other disorders such as psychiatric diseases where elevating cortisol levels would be beneficial to the subject. |
申请公布号 |
US9173884(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US201214361979 |
申请日期 |
2012.11.29 |
申请人 |
Trustees of Boston College |
发明人 |
Hoffman Charles Stuart;Ceyhan Ozge |
分类号 |
C07D495/04;A61K31/519;C07D513/04;A61K45/06;A61K31/416;A61K31/437;A61K31/53;A61K31/573 |
主分类号 |
C07D495/04 |
代理机构 |
Nixon Peabody LLP |
代理人 |
Nixon Peabody LLP |
主权项 |
1. A compound for inhibiting phosphodiesterase 11 (PDE11) selected from the group consisting of: |
地址 |
Chestnut Hill MA US |