| 发明名称 | Antibody against human prostaglandin E<sub>2 </sub>receptor EP4 | ||
| 摘要 | It is an object of the present invention to provide an antibody that binds to a human PGE2 receptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGE2 receptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined. | ||
| 申请公布号 | US9175080(B2) | 申请公布日期 | 2015.11.03 |
| 申请号 | US201113876763 | 申请日期 | 2011.09.28 |
| 申请人 | NB HEALTH LABORATORY CO., LTD. | 发明人 | Takayama Kiyoshi;Shimizu Tomoko;Urushibata Yuji;Sugimoto Yukihiko |
| 分类号 | A61K39/395;C07K16/28;C07K17/00;G01N33/88 | 主分类号 | A61K39/395 |
| 代理机构 | Westerman, Hattori, Daniels & Adrian, LLP | 代理人 | Westerman, Hattori, Daniels & Adrian, LLP |
| 主权项 | 1. A monoclonal antibody, wherein the antibody is produced from hybridomas with the international depositary accession Nos. FERM BP-11402 (NBG016-mAb14) and FERM BP-11403 (NBG016-mAb21). | ||
| 地址 | Sapporo-Shi, Hokkaido JP | ||