Antimicrobial water treatment membranes and production thereof

摘要

The present invention discloses antimicrobial water treatment membranes, comprising a water treatment membrane, covalently attached to one or more antimicrobial peptides or derivatives thereof, either directly or via one or more tether molecules. There are also provided a process for preparing these antimicrobial membranes, and uses thereof in water treatment applications.

主权项

1. An antimicrobial water treatment membrane comprising a water treatment membrane, covalently attached to one or more antimicrobial peptides or derivatives of said one or more antimicrobial peptides via one or more tether molecules, wherein said tether:
a) is an oligomer or a polymer having a molecular weight of at least 300 grams/mol, b) has an extended length, in an aqueous environment, of at least 1.5 nanometers; and c) has a ratio between said molecular weight and said extended length which is lower than 1,200 g/mol per 1 nanometer; and further wherein said antimicrobial peptide: d) has an IC50 value of up to 200 μg/ml and higher than 0, against at least one biofilm-forming microorganism, and e) is stable against proteolysis for at least 1 week.