发明名称 |
Fused aminodihydrothiazine derivatives |
摘要 |
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; R is monofluoromethyl or difluoromethyl; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.; |
申请公布号 |
US9175013(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US201213979961 |
申请日期 |
2012.01.19 |
申请人 |
Eisai R&D Management Co., Ltd. |
发明人 |
Takaishi Mamoru;Ishida Tasuku |
分类号 |
C07D513/04;A61K31/542;A61K45/06 |
主分类号 |
C07D513/04 |
代理机构 |
Fish & Richardson P.C. |
代理人 |
Fish & Richardson P.C. |
主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein
X is hydrogen or fluorine;R is monofluoromethyl or difluoromethyl. |
地址 |
Tokyo JP |