发明名称 |
Methods and compositions for tissue regeneration |
摘要 |
A kit is disclosed that includes a first component comprising alginate, wherein the first component is comprised in a first sterile vile, and a second component comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ, angiopoietin, EGF, IL-Iβ, TGFα, and TNFα, wherein the cells are allogeneic and mitotically inactive, a buffered solution, and human serum albumin or a cryoprotectant, wherein the second component is comprised in a second vial. |
申请公布号 |
US9173906(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US201414176954 |
申请日期 |
2014.02.10 |
申请人 |
Smith & Nephew, Inc. |
发明人 |
Rolland Eric;Hunziker Thomas;Chevallay Beatrice;Rinsch Christopher |
分类号 |
A61K35/36;C12N5/00;A61K38/18;A61K38/36;A61K38/48;A61L15/40;A61L26/00;A61L27/36;A61L27/38;C12N5/077;C12N5/071;A61K38/19;A61K9/00;A61K41/00;A61K47/10;A61K9/10;A61K9/19;A61K35/33;A61K48/00 |
主分类号 |
A61K35/36 |
代理机构 |
Norton Rose Fulbright US LLP |
代理人 |
Norton Rose Fulbright US LLP |
主权项 |
1. A composition comprising mitotically inactive autologous or allogeneic cells that are capable of secreting one or more biologically active molecules selected from GM-CSF, VEGF, KGF, aFGF, bFGF, TGFβ, angiopoietin, EGF, IL-1β, IL-6, IL-8, PDGF, HGF/SF, IGF-1, CSF-1, TGFα, and TNFα, wherein the composition is comprised in a buffered solution, a wound dressing, or an extracellular matrix or matrix material. |
地址 |
Memphis TN US |