| 发明名称 | Glycyrrhetinic acid-mediated nanoparticles of hepatic targeted drug delivery system, process for preparing the same and use thereof | ||
| 摘要 | Disclosed are a hepatic targeted drug delivery system and a process for preparing the same. Also disclosed is a method for treating liver cancer. | ||
| 申请公布号 | US9173852(B2) | 申请公布日期 | 2015.11.03 |
| 申请号 | US200812338966 | 申请日期 | 2008.12.18 |
| 申请人 | TIAN SI POLYMER MATERIALS TECHNOLOGY DEVELOPMENT CO.;NANKAI UNIVERSITY | 发明人 | Yuan Zhi;Huang Wei;Tian Qin;Zhang Chuangnian;Han Liang;Liu Tong;Zhang Yue;Chen Yue |
| 分类号 | A61K9/51;A61K47/36;A61K47/48 | 主分类号 | A61K9/51 |
| 代理机构 | Husch Blackwell LLP | 代理人 | Conte James B.;Husch Blackwell LLP |
| 主权项 | 1. A hepatic targeted nanoparticle comprising an anticancer agent and a carrier comprising a polysaccharide and polyethylene glycol (PEG)-glycyrrhetinic acid (GA) wherein the nanoparticle is prepared by a process comprising (a) modifying diamino-PEG with glycyrrhetinic acid (GA) to obtain a GA-modified PEG (PEG-GA); (b) physically mixing the PEG-GA with the polysaccharide to obtain a polysaccharide/PEG-GA; and (c) loading an anticancer agent to the polysaccharide/PEG-GA with an ion cross-linker to obtain the nanoparticle. | ||
| 地址 | Tianjin CN | ||