发明名称 |
Immunogenic proteins of <i>Leptospira</i> |
摘要 |
The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits. |
申请公布号 |
US9176133(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US201414534218 |
申请日期 |
2014.11.06 |
申请人 |
Cornell Research Foundation, Inc. |
发明人 |
Chang Yung-Fu;Palaniappan Raghavan U. M |
分类号 |
G01N33/53;G01N33/569 |
主分类号 |
G01N33/53 |
代理机构 |
LeClairRyan, a Professional Corporation |
代理人 |
LeClairRyan, a Professional Corporation |
主权项 |
1. An assay kit for detecting antibodies against Leptospira strains which contains at least one immunologically active purified protein derived from Leptospira interrogans wherein such protein is characterized in that it:
a. elicits an immunological response from a mammal; b. has been prepared by expression in a bacterium other than Leptospira interrogans; c. is free of other Leptospira interrogans proteins; and d. is a protein (i) comprising SEQ ID NO: 4, SEQ ID NO: 34, or SEQ ID NO: 46, or (ii) consisting of at least 9 contiguous amino acids of SEQ ID NO: 46; which protein reacts with the antibodies present in a test fluid, and wherein said kit has at least one indicator component which detects complexes of immunologically active protein and antibody. |
地址 |
Ithaca NY US |