CTRP6 which can be used as therapeutic and prophylactic agent for autoimmune diseases

摘要

Provided are methods of suppressing complement alternative pathway in a mammalian subject in need thereof, comprising administering to said subject a therapeutically effective amount of C1q and tumor necrosis factor related protein 6 (CTRP6) or a functional analog thereof.

主权项

1. A method of suppressing complement alternative pathway in a mammalian subject in need thereof, comprising administering to the subject a therapeutically effective amount of C1 q and tumor necrosis factor related protein 6 (CTRP6) or a functional analog thereof, wherein the CTRP6 or functional analog comprises the amino acid sequence selected from the group consisting of:
a) human CTRP6 (SEQ ID NO: 1); and b) the amino acid sequence having at least 95% sequence identity with C1 q domain of human CTRP6 and activity to suppress complement activation.