Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile and process for the synthesis of ivabradine and addition salts thereof with the use thereof

摘要

The invention relates to a process for the synthesis of the compound of formula (I):characterized in that the compound of formula (VIII):is subjected to the action of N-bromosuccinimide in the presence of an organic solvent to yield the compound of formula (I).The invention further relates to a process for the synthesis of ivabradine, pharmaceutically acceptable salts thereof and hydrates thereof using the compound of formula (I). Said process provides a high yield percent of the finished product.