Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation

摘要

Disclosed is use of a composition comprising an amount of a MASP-2 inhibitory agent effective to selectively inhibit MASP-2 dependent complement activation in a subject suffering from, or at risk for developing a complement-mediated coagulation disorder in the manufacture of a medicament for treating a subject suffering from, or at risk for developing, a complement-mediated coagulation disorder, wherein the complement mediated disorder is secondary to at least one of: a deficiency in a complement regulatory factor, a traumatic injury, an infection, a malignancy, surgery, a transplant rejection, a transfusion reaction, an obstetric complication, a vascular aneurysm, hepatic failure, heat stroke, burn, radiation exposure, or severe toxic reaction, and wherein the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof that binds to a portion of SEQ ID NO:6; wherein the sequences are as defined in the complete specification.