| 摘要 |
Disclosed is a fusion protein of formula I: (X)m - (R1)n - A - (Y)o - B - (Z)p (formula I) wherein: X is a signal peptide or MHHHHHH; m is 0 or 1; R1 is an amino acid; n is 0, 1, 2, 3, 4, 5 or 6; A is Protein E from Haemophilus influenzae or an immunogenic fragment thereof, or PilA from Haemophilus influenzae or an immunogenic fragment thereof; Y is selected from the group consisting of GG, SG, SS, GGG and (G)h wherein h is 4, 5, 6, 7, 8,9, or 10; o is 0 or 1; B is PilA from Haemophilus influenzae or an immunogenic fragment thereof, or Protein E from Haemophilus influenzae or an immunogenic fragment thereof; Z is GGHHHHHH (SEQ 10 NO.3); and p is 0 or 1, wherein when A is Protein E from Haemophilus influenzae or an immunogenic fragment thereof, B is not Protein E from Haemophilus influenzae or an immunogenic fragment thereof; and wherein when A is PilA from Haemophilus influenzae or an immunogenic fragment thereof, B is not PilA from Haemophilus influenzae or an immunogenic fragment thereof. Also disclosed is an immunogenic composition comprising isolated Protein E from H. influenzae and isolated PilA from H. influenzae |
