Methods for predicting anti-cancer response

摘要

Disclosed is an assay for selecting therapy for a subject having cancer, the assay comprising subjecting a biological sample comprising a cancer cell or nucleic acid from a cancer cell taken from the subject to telomeric allelic imbalance (tAI) analysis; detecting the number of telomeric allelic imbalance (NtAI) in the cancer cell or nucleic acid from the cancer cell, and selecting a treatment regimen comprising chemotherapy and/or a synthetic lethality agent for the subject when the NtAI is detected to be above a reference value based on the recognition that the treatment regimen comprising chemotherapy and/or a synthetic lethality agent is effective in patients who have NtAI above the reference value; and selecting a treatment regimen not comprising chemotherapy and/or a synthetic lethality agent for the subject when the NtAI is detected to be below a reference value based on the recognition that treatment regimen comprising chemotherapy and/or a synthetic lethality agent is not effective in patients who have the NtAI below a reference value.