发明名称 |
COMPOSITION FOR LOCAL AND CONTROLLED RELEASE OF DRUGS AND METHODS THEREOF |
摘要 |
The present disclosure relates to a composition for treatment and/or prevention of infections, namely bone diseases, in particular osteomyelitis, via a controlled release of antibiotics and subsequently induce regeneration of bone tissue that often undergoes necrosis due to infection. The present disclosure relates in particular to a pharmaceutical composition comprising one or more granules containing calcium phosphate, collagen and one or more polymers of heparin, and an antibiotic in an effective therapeutic amount, wherein the antibiotic is bound to the heparin polymers. |
申请公布号 |
WO2015162561(A1) |
申请公布日期 |
2015.10.29 |
申请号 |
WO2015IB52916 |
申请日期 |
2015.04.21 |
申请人 |
INEB - INSTITUTO NACIONAL DE ENGENHARIA BIOMÉDICA;UNIVERSIDADE DO PORTO;ISEP - INSTITUTO SUPERIOR DE ENGENHARIA DO PORTO |
发明人 |
MONTEIRO, FERNANDO JORGE;RIBEIRO E SOUSA MENDES DE FREITAS, SUSANA MARIA;COELHO, CATARINA;ALEGRETE DA SILVA, NUNO PAULO |
分类号 |
A61K9/00;A61K9/16;A61K31/43;A61K38/14;A61L27/12;A61L27/20;A61L27/24;A61L27/54;A61P19/00;A61P19/08 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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