MANAGEMENT OF BREAKTHROUGH BLEEDING IN EXTENDED HORMONAL CONTRACEPTIVE REGIMENS

摘要

PROBLEM TO BE SOLVED: To provide a flexible extended use regimen for a hormonal contraceptive useful to manage bleeding problems associated with fixed extended use of hormonal contraceptives and to a pharmaceutical package containing the respective hormonal contraceptive.SOLUTION: There is provided a composition for female hormonal contraception which includes the monophasic continuous administration of ethinyl estradiol in an amount of 5 to 30 μg or another estrogen in an amount equivalent to 5 to 30 μg ethinyl estradiol and a progestin in a contraceptive amount to the female for a first minimum period for as long as desired by the woman. After the period, the female initiates an active preparation break of 1 to 6 days and the break is followed by at least one further administration cycle of at least the duration of the first minimum period.